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Physical Properties
Molecular weight:376.7; Physical form:Odourless, colourless crystals; ( tech. is a mildly aromatic, golden brown liquid, that tends to solidify on cooling). Density:1.42 (20 °C); Composition:Tech. grade is c. 97% pure. Melting point:46.5-49.3 °C (>99% pure); Flash point:160 °C (closed cup); Vapour pressure:1.5 ×10-1 mPa (25 °C); 9.0 ×10-2 mPa (20 °C); Henry constant:1.64 × 10-3 Pa m3 mol-1 ( calc.); Partition coefficient(n-octanol and water):logP = 4.12 (unionised); pKa:3.8, weak base; Solubility:In water 34.4 mg/l (25 °C). Readily soluble in a wide range of organic solvents, e.g. chloroform, diethyl ether, toluene, xylene 2.5, acetone 3.5, hexane c. 7.5 ×10-3 (all in kg/l; Stability:No degradation after 30 d (pH 5-7, 22 °C). Decomposes in concentrated acids and alkalis, in the presence of sunlight, and on prolonged heating at high temperatures (200 °C).
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Toxicology
Oral:Acute oral LD50 for rats 1600-2400, mice 2400 mg/ kg. Percutaneous:Acute percutaneous LD50 for rats >2100, rabbits >3000 mg/kg. Not irritating to skin; slight eye irritation (rabbits). Inhalation: LC50 (4 h) for rats >2.16 mg/l air.
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Environmental Profile
Ecotoxicology:
Algae: EbC50 (72 h) for Selenastrum capricornutum 0.1 mg/l; ErC50 1.54 mg/l.Bees:Low toxicity to bees. LD50 (topical) 50µg/bee; (oral) 60µg/bee.Birds:Acute oral LD50 for bobwhite quail 662, mallard ducks >1954 mg/kg. Dietary LC50 (5 d) for bobwhite quail and mallard ducks >5200 mg/ kg.Daphnia: LC50 (48 h) 4.3 mg/l.Fish: LC50 (96 h) for rainbow trout 1.5, bluegill sunfish 2.2 mg/l.Worms: LC50 for earthworms (Eisenia foetida) 207 mg/ kg soil.Other aquatic spp.: EC50 (96 h) for Eastern oyster (Crassostrea virginica) 0.95, mysid shrimp (Mysidopsis bahia) 0.77 mg/l.Other beneficial spp.:Low toxicity to a range of beneficial arthropods.
Environmental fate:
Animals:In all species examined, prochloraz is rapidly metabolised initially by cleavage of the imidazole ring and quantitatively eliminated from the body, following oral administration. Whilst absorption following dermal exposure is low, residues in plasma and tSoil:Degrades in the soil to a range of mainly volatile metabolites (degradation is not pH-dependent). Prochloraz is well adsorbed onto soil particles, and is not readily leached; Kd 152 (sandy loam), 256 (silty claPlant:The primary plant metabolite, N-formyl-N'-1-propyl-N-(2-(2,4,6-trichlorophenoxy)ethyl)urea, is formed from cleavage of the imidazole ring. This is degraded to N-propyl-N-(2-(2,4,6-trichlorophenoxy)ethyl)urea. WATER SOLUBILITY: Low solubility, 34.4 mg/l at 25°Ced and not readily leached.
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Transport Information
Signal Word:CAUTION; Hazard Class:III(Slightly hazardous)