Profoxydim

Profoxydim

环苯草酮

(5RS)-2-{(EZ)-1-[(2RS)-2-(4-chlorophenoxy)propoxyimino]butyl}-3-hydroxy-5-[(3RS)-thian-3-yl]cyclohex-2-en-1-one

2-[1-[[2-(4-chlorophenoxy)propoxy]imino]butyl]-3-hydroxy-5-(tetrahydro-2H-thiopyran-3-yl)-2-cyclohexen-1-one

139001-49-3

C₂₄H₃₂ClNO₄S

Herbicides > Cyclohexene oxime herbicides

Herbicide

Molecular weight:466.0; Physical form:Colourless, odourless, highly viscous liquid. Density:1.198 (20 °C); Composition:Tech. is 91%. Flash point:>100 °C (EEC A9); Vapour pressure:1.7 ×10-1 mPa (20 °C, EEC A4); Henry constant:1.76 × 10-2 Pa m3 mol-1 (calc.); Partition coefficient(n-octanol and water):logP = 3.9 (25°C); pKa:5.91 (20 °C); Solubility:In water 5.31 mg/l (20 °C). In acetone >70, isopropanol 33, ethyl acetate >70 (all in g/100 g, 20 °C).; Stability:Hydrolytic stability: instantly degraded at pH 5; DT50 c. 140 d (pH 7), >300 d (pH 9).

Oral:Acute oral LD₅₀ for male and female rats >5000 mg/ kg. Percutaneous:Acute percutaneous LD₅₀ for male and female rats >4000 mg/kg. Non-irritating to skin and eyes (rabbits). Inhalation: LC₅₀ (4 h) for rats >5.2 mg/l. ADI:0.05 mg/ kg b.w.

Ecotoxicology: 
Algae: E_rC₅₀ (96 h) for Anabaena flos-aquae 33 mg/l.Bees: LD₅₀ (oral and contact, 48 h) >200 ×g/bee.Birds:Acute oral LD₅₀ for bobwhite quail >2000 mg/kg. Dietary LC₅₀ (8 d) for bobwhite quail >5000 mg/kg.Daphnia: LC₅₀ (48 h) 18.1 mg/l.Fish: LC₅₀ (96 h) for rainbow trout 13-18, bluegill sunfish 24-36 mg/l.Worms: LC₅₀ (14 d) for earthworms >1000 mg/kg soil.Other beneficial spp.:'Aura' + 'Dash HC' harmless to slightly harmful for Aphidius rhopalosiphi, Aleochara bilineata, Chrysopa carnea (lab.). 

Environmental fate:
 Animals:Slowly and incompletely absorbed orally in rats; excretion is rapid and mainly via the urine; no accumulation was observed in any tissue or organ. A large number of metabolites is detected, formed by three main pathways: oxidation of the thioether to the Soil:Rapidly degraded in soil; DT₅₀ 3-13 d; shorter under the influence of sunlight and in rice cultivation conditions. Mineralisation of all three rings of the molecule is up to 52%. In aerobic and anaerobic water/sediment systems, Plant:Rapid and intensive metabolism by oxidation, ether cleavage and desalkoxylation of the side chain. WATER SOLUBILITY: 0.53 mg/100g at 20°C HAZARDS: NOEC. Fish: 12.8 mg/l (96 h) (rainbow trout); 10.9 mg/l (48 h) (Daphnia). Bird: LD₅₀ >2000 mg/kg (quail)

Hazard Class:O (Obsolete as pesticide, not classified)