Tetraconazole

Tetraconazole

四氟醚唑

(RS)-2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl 1,1,2,2-tetrafluoroethyl ether

1-[2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]-1H-1,2,4-triazole

112281-77-3

C₁₃H₁₁Cl₂F₄N₃O

Fungicides > Triazole fungicides

Fungicide

Tetraconazole has curative and protectant activity. Like all triazoles it is systemic; it also has translaminar activity. It is generally applied as a foliar spray, but can also be used as a cereal seed treatment. On cereals, one foliar application can control diseases for up to six weeks, although a second application is recommended. Fruit and flowers require applications at approximately two-week intervals.

In field trials, tetraconazole showed no phytotoxicity to target crops. It gave better control of diseases than standard fungicides used at similar or higher rates.

CropUses:
Cereals, coffee, fruit, vines, ornamentals, peanuts, sugar beet, turf, vegetables

Cereals: 125 g ai/ha	Vines: 25-40 g ai/ha
Sugar beet: 60-100 g ai/ha	Apples: 25-40 g ai/ha
Vegetables: 40-60 g ai/ha	Peaches: 40-50 g ai\ha

Tetraconazole+Trifloxystrobin
Tetraconazole+Pyraclostrobin
Tetraconazole+Kresoxim-methyl
Tetraconazole+Azoxystrobin
fluxapyroxad+pyraclostrobin+tetraconazole
Chlorothalonil+tetraconazole
Emulsifiable concentrate, oil-in-water emulsion, liquid for seed treatment, micro-emulsion. Premix Parters: cyfluthrin piperonyl butoxide propoxur; lambda-cyhalothrin piperonyl butoxide; cypermethrin; cypermethrin piperonyl butoxide; fenitrothion; permethrin; permethrin piperonyl butoxide; piperonyl butoxide; resmethrin;

 

 

Type	AI concn
Emulsifiable concentrate (EC)	15% (w/v)
Oil-in-water emulsion (EW)	12.5% (w/v)
Liquid seed treatment (LS)	12.5% (w/v)
Soluble concentrate (SL)	12.5% (w/v)

Molecular weight:372.1; Physical form:Colourless, viscous liquid; ( tech., yellow to yellowish-brown liquid). Density:1.432 (20 °C); Melting point:Pour point 6 °C; Vapour pressure:0.18 mPa (gas saturation method); Henry constant:3.6 × 10-4 Pa m3 mol-1 (20 °C, calc.); Partition coefficient(n-octanol and water):logP = 3.56 (20 °C); Solubility:In water 156 mg/l ( pH 7, 20 °C). Readily soluble in 1,2-dichloroethane, acetone, and methanol.; Stability:Stable in dilute aqueous solutions at pH 4-9. Stable in water to sunlight.;

Oral:Acute oral LD₅₀ for male rats 1248, female rats 1031 mg/kg. Percutaneous:Acute percutaneous LD₅₀ for rats >2000 mg/kg. Not irritating to skin; slightly irritating to eyes (rabbits). Not a skin sensitiser (guinea pigs). Inhalation:LC₅₀ (4 h) for rats >3.66 mg/l.

Ecotoxicology:
 Bees:LD₅₀ (oral) >130 µg/bee.Birds:Dietary LC₅₀ (5 d) for bobwhite quail 650, mallard ducks 422 mg/kg.Daphnia:LC₅₀ (48 h) 3.0 mg/l.Fish: LC₅₀ (96 h) for rainbow trout 4.8, bluegill sunfish 4.3 mg/l. 

Environmental fate: 
Animals:Tetraconazole is readily adsorbed, metabolised and excreted with no significant retention in the tissues. The main metabolite identified in urine of rats is 1,2,4-triazole.Soil:No accumulation in the field. No leaching occurs in standard soils. K_oc 531-1922 in 4 soil types.Plant:Extensive metabolism occurs in plants. The identified metabolites are tetraconazole acid, tetraconazole alcohol, triazolylalanine and triazolylacetic acid.

Bobwhite quail	LD50 650 mg/kg
Mallard duck	LD50 422 mg/kg
Rainbow trout [96 h]	LC50 4.8 mg/L
Bluegill sunfish	LC50 4.0 mg/ml
Bee [contact]	LD50>100 μg/bee

Fate in soil:
Tetraconazole is not expected to accumulate in soil or to leach under standard field conditions.

Fate in aquatic systems:
Tetraconazole does not undergo photolysis in water.

Hazard Class:II(Moderately hazardous)