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Physical Properties
Molecular weight:310.5; Physical form:Tech. is a pale yellow liquid, with a fruity odour. Density:0.924 (20 °C), 0.921 (25 °C); Composition:Except where indicated otherwise, all data refer to the (RS)- (E,E)- isomer pair. Flash point:136 °C (closed cup); Vapour pressure:0.79 mPa (25 °C, gas saturation method); Henry constant:4.76 × 10-1 Pa m3 mol-1 ( calc.); Partition coefficient(n-octanol and water):logP >6; Solubility:In water 0.76 mg/l (20 °C); ((S)-methoprene) 6.85 mg/l (20 °C). Miscible with all common organic solvents.; Stability:Stable in water, organic solvents, and in the presence of aqueous acids and alkalis. Sensitive to u.v. light.;
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Toxicology
Oral:Acute oral LD50 for rats >5000 mg/kg. Percutaneous:Acute percutaneous LD50 for rabbits >2000 mg/kg, ((S)- isomer >5050 mg/kg). Non-irritating to eyes, moderately irritating ((S)- isomer slight Inhalation: LC50 for rats >4.94 mg/l, ((S)- isomer >2.38 mg/l). ADI:( JMPR) 0.03 mg/kg b.w. [1994].
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Environmental Profile
Ecotoxicology:
Algae: EC50 (48-96 h) for Scenedesmus subspicatus 1.33 mg/ml.Bees:Non-toxic to adult bees; LD50 (oral and topical) >1000 mg/bee. Bee larvae are sensitive at 0.2 mg/bee.Birds:Dietary LC50 (8 d) for chickens >4640 mg/ kg.Daphnia: LC50 (48 h) 360 mg/l.Fish: LC50 (96 h) for bluegill sunfish 4.6, trout 4.4 mg/l.Other aquatic spp.:Toxic to aquatic Diptera.
Environmental fate:
Animals:In mammals, the secondary metabolite cholesterol has been identified.Soil:In soil, rapidly degraded, DT50 c. 10 d.Plant:In plants, degradation principally involves ester hydrolysis, O-demethylation, and oxidative cleavage of the double bond at the 4-position. In alfalfa and rice, the principal metabolite is 7-methoxycitronellal.
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Transport Information
Signal Word:CAUTION; Hazard Class:III(Slightly hazardous)