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Triazole Fungicides Insight

Mechanism & Application

Triazoles have no effect against spore germination because spores contain enough sterol for the formation of germ tubes. Some spores even have enough sterol to produce infection structures so, in some cases, triazoles may not be effective against infection of the host tissue. The fungicides are used on many different types of plants in Iowa including field crops, fruit trees, small fruit, vegetables, and turf. These fungicides are highly effective against many different fungal diseases, especially powdery mildews, rusts, and many leaf-spotting fungi.

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Market Overview

The triazole fungicides have replaced the benzimidazoles to be the best-selling products with their unique mode of function and broad spectra. Since the first triazole fungicide, triadimefon launched by Bayer in the 1970s, nearly 40 triazoles have been commercialized by the agrochemical companies and fungicides such as tebuconazole, epoxiconazole and difenoconazole were the most popular triazoles fungicides. Key products in this group ranked by annual sales in 2007 are listed below:

Product Sales ($ million)
2005 2007
tebuconazole 505 485
epoxiconazole 295 345
difenoconazole 135 195
propiconazole 140 185
cyproconazole 45 175
flusilazole 90 95
myclobutanil 55 75
tetraconazole 80 65
flutriafol 70 65
triadimenol 55 60

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Products to be Off-patent

The triazoles are also well chased by the generic players as some of the products to be off-patent in the near future. Following are their profiles inoder to feed our readers.

Common Name CAS No. Patent Status
bromuconazole 116255-48-2 U.S patent will be expired in 2015.
fenbuconazole 135410-20-7 Off-patent in 2009.
fluquinconazole 136426-54-5 EP0702007 will be expired in 2018.
metconazole 125116-23-6 Off-patent in 2007, but its data will be proteted until June 2012.
myclobutanil 88671-89-0 US5688742 will be expired in 2015.
tebuconazole 107534-96-3 US6191128 will be expired in 2017.
triticonazole 131983-72-7 Off-patent in 2010.

ICAMA Report

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Key Players & Commercial Products

Due to the great market influence, the triazoles field has become the arena of the MNCs and the products have become the flagships in their portfolios. The difenoconazole from Syngenta and tebuconazole from Bayer, respectively ranked in the top ten products with annual sales of $210 million and $354 million in 2008. The Epoxiconazole from BASF, ranked second best-selling and became a mainstay of the company. Key players in this field and details of the products are listed below:

Active Ingredient Trademark Combination
BASF
Epoxiconazole Opus®, Opus Team®, Duett®, Opal® pyraclostrobin, fenpropimorph, pyraclostrobin,
Metconazole Caramba®
Twinline®
pyraclostrobin
Triticonazole Alios®, Stamina® F3 HL pyraclostrobin, metalaxyl
Bayer
Tebuconazole OnlyOne, Horizon, Silvacur, Elite, Folicu,  
Falcon, Folicur BT, Matador, Milord , Pronto Plus, Prosaro, Nativo Arena® C, Raxil®, Raxil® Extra, Raxil® T spiroxamine, triadimenol, triadimefon, prothioconazole, trifloxystobin fludioxonil, thiram, metalaxyl
Triadimefon Bayleton®  
Bitertanol Baycor®, Baycoral®, Proclaim® dodine
Triadimenol Bayfidan®, Baysiston®, Exact® disulfuton
Syngenta
Difenoconazole ARMURE®, TASPA®, SICO®, INSPIRE®  
Propiconazole TILT®  
Cyproconazole Elite®, ALTO Super®, ARTEA®, MENARA®, CHEROKEE®,  

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Brand Product

Strike is a systemic fungicide that controls or prevents many fungal diseases on ornamental plants in the greenhouse and nursery. Diseases controlled include flower blight, leaf blight/spot, powdery mildew, rusts and tip blights. Strike works from inside the plant to actively control diseases before symptoms occur and will provide residual control for 30 days or more.

OHP, Inc.
P.O. Box 230,Mainland, PA 19451
Tel:1+(800) 659-6745
Contact a Regional Sales Manager

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