Pyrazophos

Pyrazophos

吡菌磷

ethyl 2-diethoxyphosphinothioyloxy-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate
or
O-6-ethoxycarbonyl-5-methylpyrazolo[1,5-a]pyrimidin-2-yl O,O-diethyl phosphorothioate

ethyl 2-[(diethoxyphosphinothioyl)oxy]-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate

13457-18-6

C₁₄H₂₀N₃O₅PS

Insecticides > Organophosphorus insecticides
Fungicides > Organophosphorus fungicides

Fungicide

Emulsifiable concentrate. 
Premix Parters: chlorpropham piperonyl butoxide; lindane; permethrin; pheromone; piperonyl butoxide; rotenone;

Molecular weight:373.4; Physical form:Colourless crystals. Density:1.348 at 25 °C; Composition:Tech. grade is >94% pure. Melting point:51-52 °C; Flash point:34 °C (Abel-Pensky closed method); Vapour pressure:0.22 mPa (50 °C) (Antoine); Henry constant:2.578 × 10-4 Pa m3 mol-1 (calc.); Partition coefficient(n-octanol and water):logP = 3.8; Solubility:In water 4.2 mg/l (25 °C). Readily soluble in most organic solvents, e.g. xylene, benzene, carbon tetrachloride, dichloromethane, trichloroethylene. In acetone, toluene, ethyl acetate >400, hexane 16.6 (all in g/l, 20 °C).; Stability:Hydrolysed by acids and alkalis. Unstable in undiluted form.

Oral:Acute oral LD₅₀ for rats 151-778 mg/ kg (depending on sex and carrier). Percutaneous:Acute percutaneous LD₅₀ for rats >2000 mg/kg. Non-irritating to skin; slightly irritating to eyes (rabbits). Inhalation: LC₅₀ (4 h) for rats 1220 mg/m³ air. Phytotoxicity:Non-phytotoxic when used as recommended (except to some varieties of grape). ADI:(Japan) 0.006 mg/ kg.

Ecotoxicology: 
Algae: LC₅₀ (72 h) for Scenedesmus subspicatus 65.5 mg/l.Bees: LD₅₀ (24 h, contact) 0.25µg/bee.Birds:Acute oral LD₅₀ for quail (depending on carrier and sex) 118-480 mg tech./kg. Dietary LC₅₀ (14 d) for mallard ducks c. 340, bobwhite quail c. 300 50 (48 h) 0.36µg/l (soft water), 0.63µg/l (hard water). 50 (96 h) for carp 2.8-6.1, rainbow trout 0.48-1.14, bluegill sunfish 0.28 mg/l.Worms: LC₅₀ (14 d) for Eisena foetida >1000 mg/ kg soil.Other beneficial spp.:'Afugan 30 EC' rated harmful to Poecilus cupreus, Syrphus corollae, Chrysoperla carnea and Aleochara bilineata; harmless to Pardosa amentata (IOBC scheme). 

Environmental fate: 
Animals:Extensively metabolised and rapidly eliminated in rats, DT₅₀ 4-5 h. Excretion mainly in urine; the most important metabolite is ethyl 2-hydroxy-5-methyl-6-pyrazolo[1,5-a]pyrimidine-carboxylate, partly excreted as a sulfSoil:Soil degradation occurs by cleavage of the phosphoric acid group, saponification of the carboxylate fraction and further degradation of the heterocyclic ring system, ultimately to CO₂. Degradation rates vary with soil type and properties, with Plant:Half-life in wheat leaves c. 19 d. Following hydrolysis of the phosphate bond, a b-glucoside of the pyrazolopyrimidine is formed. WATER SOLUBILITY: 4.2 mg/l at 25°C

Signal Word:WARNING; Hazard Class:II(Moderately hazardous)