Chemical Identification
Common Name
Chlorothalonil
中文通用名
百菌清
IUPAC
tetrachloroisophthalonitrile
CAS
2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile
CAS No.
1897-45-6
Molecular Formula
C8Cl4N2
Molecular Structure
Category
Activity
Fungicide
Chlorothalonil is a broad-spectrum organochlorine pesticide (fungicide) used to control fungi that threaten vegetables, trees, small fruits, turf, ornamentals, and other agricultural crops. It also controls fruit rots in cranberry bogs, and is used in paints. 
Chlorothalonil reduces fungal intracellular glutathione molecules to alternate forms which cannot participate in essential enzymatic reactions, ultimately leading to cell death, similar to the mechanism of trichloromethyl sulfenyl.
CropUse
rice, wheat, vegetables, fruit trees, peanuts, tea leaves, rubber trees, forests and golf course grasses. 
Pest Spectrum
mold, mildew, bacteria, algae ect.
Formulation
WG = Water dispersible granules
WP = Wettable powder
Premix
Chlorothalonil+azoxystrobin
Chlorothalonil+carbendazim
Chlorothalonil+oxine-copper
Chlorothalonil+copper oxychloride
Chlorothalonil+cymoxanil
Chlorothalonil+cyproconazole
Chlorothalonil+cyproconazole+propiconazole
Chlorothalonil+difenoconazole
Chlorothalonil+dimethomorph
Chlorothalonil+fludioxonil+propiconazole
Chlorothalonil+fluoxastrobin
Chlorothalonil+hexaconazole
Chlorothalonil+iprodione
Chlorothalonil+metalaxyl
Chlorothalonil+metalaxyl-M
Chlorothalonil+propamocarb hydrochloride
Chlorothalonil+propiconazole
Chlorothalonil+pyrimethanil
Chlorothalonil+sulfur
Chlorothalonil+tetraconazole
Chlorothalonil+thiophanate-methyl
Chlorothalonil+vinclozolin
Chlorothalonil+tebuconazole
Chlorothalonil+mancozeb
Chlorothalonil+zineb
Chlorothalonil+carbendazim+thiram
Chlorothalonil+thiram
Chlorothalonil+thiram+ziram
Chlorothalonil+procymidone
Chlorothalonil+dimetachlone
Chlorothalonil+prochloraz+triadimefon
Chlorothalonil+thiabendazole
Chlorothalonil+fosetyl-aluminium
Chlorothalonil+diniconazole
Chlorothalonil+diethofencarb
Triticonazole+chlorothalonil
Chlorothalonil+mandipropamid
zoxamide+chlorothalonil
Physical Properties
Molecular weight:265.9; Physical form:Colourless, odourless crystals; (tech. has a slightly pungent odour). Density:2.0 (20 °C); Composition:Tech. is c. 97%. Melting point:252.1 °C; Vapour pressure:0.076 mPa (25 °C); Henry constant:2.50×10-2 Pa m3 mol-1 (25 °C); Partition coefficient(n-octanol and water):logP = 2.92 (25 °C); Solubility:In water 0.81 mg/l (25 °C). In xylene 80, cyclohexanone, dimethylformamide 30, acetone, dimethyl sulfoxide 20, kerosene <10 (all in g/kg, 25 °C).; Stability:Thermally stable at ambient temperatures. Stable to u.v. light in aqueous media and in crystalline state. Stable in acidic and moderately alkaline aqueous solutions; slow hydrolysis at pH >9. Thermally stable under normal storage conditions. Stable to ultraviolet radiation. Stable in neutral or acidic aqueous media. Half- life of 38.1 days in aqueous media at pH 9. Non-corrosive. Nonvolatile under normal field conditions. Slightly soluble in xylene, acetone.
Toxicology
Oral:Acute oral LD50 for rats >5000 mg/kg. Percutaneous:Acute percutaneous LD50 for albino rabbits >10 000 mg/kg. Severe eye irritant; mild skin irritant (rabbits). Evidence in humans of contact dermatitis. Inhalation:LC50 (1 h) for rats >4.7 mg/l air; (4 h) for rats (nominal concentration) 0.62 mg/l air; (4 h) for rats (actual) 0.10 mg/l air. Phytotoxicity:Russetting is possible with flowering ornamentals, apples, and grapes. Some varieties of flowering
Environmental Profile
Ecotoxicology: Algae:For Selenastrum capricornutum, EC50 (120 h) 0.21 mg/l, NOEC (120 h) 0.1 mg/l.Bees:No more than slightly toxic.Birds:Acute oral LD50 for mallard ducks >4640 mg/kg. Dietary LC50 (8 d) for mallard ducks and bobwhite quail >10 000 mg/kg diet.Daphnia:LC50 (48 h) 70 μg/l.Fish:LC50 (96 h) for rainbow trout 47 μg/l, bluegill sunfish 60 μg/l, channel catfish 43 μg/l.Worms: LC50 (14 d) >1000 mg/ kg.Other aquatic spp.:LC50 (96 h) for pink shrimp 165 μg/l. Environmental fate: Animals:Chlorothalonil is not well absorbed following oral dosing. It reacts with glutathione in the gut lumen, or immediately on absorption into the body, to give mono-, di- or tri- glutathione conjugates. These may be excreted through urine or faeces, or subjecSoil:Koc 1600 (sand) to 14 000 (silt), indicating low mobility to immobile. In aerobic and anaerobic soil studies, DT50 is 5-36 d. Degradation is faster in biotic aquatic systems, typical DT50. Plant:In plants, the majority of the residue remains as parent compound. The most abundant metabolite, 4-hydroxy-2,5,6-trichloroisophthalonitrile, is generally <10% of applied parent.
WATER SOLUBILITY: Insoluble, 0.6-1.2 ppm.
Transport Information
Signal Word:DANGER; Hazard Class:Ib (Highly hazardous)

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