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Chemical Identification
Common Name
Hexythiazox
中文通用名
噻螨酮
IUPAC
(4RS,5RS)-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-1,3-thiazolidine-3-carboxamide
CAS
trans-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxamide
CAS No.
78587-05-0
Molecular Formula
C17H21ClN2O2S
Molecular Structure
Category
Activity
Acaricide/Miticide
Premix
Fenpropathrin+hexythiazox
Bifenthrin+Hexythiazox
Flowable, wettable powder, emulsifiable concentrate.
Premix partners:Dicofol; Propargite
Physical Properties
Molecular weight:352.9g/mol; Physical form:Colourless crystals. Melting point:108.0-108.5℃; Vapour pressure:0.0034 mPa (20℃); Henry constant:2.40×10-3Pa m3 mol-1 (calc.); Partition coefficient(n-octanol and water):logP = 2.53; Solubility:In water 0.5 mg/l (20℃). In chloroform 1379, xylene 362, methanol 206, acetone 160, acetonitrile 28.6, hexane 4 (all in g/l, 20℃).; Stability:Stable to light, air and heat, and in acidic and alkaline media. Stable to 300℃. Aqueous solution in sunlight DT50 16.7 d.
Toxicology
Oral Acute oral LD50 for rats and mice >5000 mg/kg.Skin and eye Acute percutaneous LD50 for rats >5000 mg/kg. Mild eye irritant; non-irritating to skin (rabbits).Non-sensitising to skin (guinea pigs).Inhalation LC50 (4 h) for rats >2 mg/l air.
Environmental Profile
Ecotoxicology:
Birds Acute oral LD50 for mallard ducks >2510, Japanese quail >5000 mg/kg.Dietary LC50 (8 d) for mallard ducks and bobwhite quail >5620 mg/kg diet.Fish LC50 (96 h) for rainbow trout >300, bluegill sunfish 11.6 mg/l; (48 h) for carp 3.7 mg/l.Daphnia LC50 (48 h) 1.2 mg/l.Bees Not toxic to bees.LD50 by topical application >200 mg/bee.

Environmental fate:
Animals The main metabolite in urine and faeces is 5-(4-chlorophenyl)-N-(cis-4-hydroxycyclohexyl)-4-methyl-trans-2-oxothiazolidine-3-carboxamide.  Soil/Environment DT50 in clay loam at 15, 8 d. In soil, undergoes oxidation to the corresponding hydroxy and carbonyl compounds. Koc 6200.
Transport Information
Signal Word:CAUTION; Hazard Class:III(Slightly hazardous)

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