Ecotoxicology:
Algae: EC
50 (5 d) for
Selenastrum 0.072,
Anabaena 0.29,
Navicula 0.43,
Skeletonema 0.38 mg/l.Birds:Acute oral LD
50 for bobwhite quail 560 mg/kg. Dietary LC
50 (8 d) for bobwhite quail >5000 ppm, for mallard ducks 1650 mg/ kg.Daphnia: LC
50 (48 h) 4.9 mg/l.Fish: LC
50 (216 h) for rainbow trout 1.21, bluegill sunfish 3.27 mg/l.Other aquatic spp.: LC
50 (96 h) for mysid shrimp (
Mysidopsis bahia) 2.5, oyster (
Crassostrea) 3.0 mg/l.
Environmental fate:
Animals:In mammals, following oral administration, the water-soluble metabolite 3-carboxy-5-ethoxy-1,2,4-thiadiazole has been found. In rat urine, this compound was found as a major metabolite and
N-acetyl-
S-(5-ethoxy-1,2,4-thiadiazol-3-yl-methySoil:Soil
50 in silt loam in laboratory at 25 °C (aerobic) 9.5 d, (anaerobic) 3 d. Field dissipation, in sandy clay loam, DT
50 1 w. Soil adsorption K 5.31 (sandy soil), 1.41 (silt loam).Plant:The trichloromethyl group is readily converted to the acid or alcohol, and the ethoxy group is hydroxylated to form a hydroxyethyl derivative. Some plants convert etridiazole more extensively to form natural products.