Ofurace

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Chemical Identification | General Product Information | Physical & Safety Data

Chemical Identification

Common Name

Ofurace

中文通用名

呋酰胺

IUPAC

(RS)-α-(2-chloro-N-2,6-xylylacetamido)-γ-butyrolactone

CAS

2-chloro-N-(2,6-dimethylphenyl)-N-(tetrahydro-2-oxo-3-furanyl)acetamide

CAS No.

58810-48-3

Molecular Formula

C₁₄H₁₆ClNO₃

Molecular Structure

General Product Information

Category

Fungicides > Anilide fungicides

Activity

Fungicide

Physical & Safety Data

Physical Properties

Molecular weight:281.7; Physical form:Colourless crystals; ( tech. is an off-white to light beige, crystalline powder). Density:1.43 (20℃); Composition:Tech. grade is 97% pure. Melting point:145-146℃; Vapour pressure:2 × 10-2 mPa (20℃); Henry constant:3.9 × 10-5 Pa m3 mol-1 (calc.); Partition coefficient(n-octanol and water):logP = 1.39 (20℃); Solubility:In water 146 mg/l (20 ℃). In acetone 60-75, 1,2-dichloroethane 300-600, ethyl acetate 25-30, methanol 25-30, p-xylene 8.6, heptane 0.0322 (all in g/l).; Stability:Hydrolysis is rapid in alkali, DT50 7 h (pH 9, 35 ℃), but stable in acidic media and at elevated temperatures. Photochemical degradation in water, DT50 7 d.

Toxicology

Oral:Acute oral LD₅₀ for male rats 3500, female rats 2600, mice >5000, rabbits >5000 mg/ kg. Percutaneous:Acute percutaneous LD₅₀ for rabbits >5000 mg/kg. Moderate eye irritant; mild skin irritant (rabbits). Not a skin sensitiser (guinea pigs). Inhalation: LC₅₀ for rats 2060 mg/m³.

Environmental Profile

Ecotoxicology:
Bees:Non-toxic to bees; LD₅₀ (oral) >58 μg/bee.Birds:Acute oral LD₅₀ for red-legged partridge >5000 mg/ kg.Daphnia:EC₅₀ (48 h) 46 mg/l.Fish: LC₅₀ (96 h) for rainbow trout 29, golden orfe 57 mg/l.

Environmental fate:
Animals:Ofurace is rapidly excreted, undergoing extensive phase I and phase II biotransformation.Soil:Degraded in soil, field 50 c. 26 d. Only moderately adsorbed to soil and is considered to be moderately mobile. Undergoes photochemical degradation in water and is degraded in water sediment systems.Plant:Similar metabolic pathways have been detected in vines, tomatoes, and potatoes. Ofurace is relatively stable on the plant surface, but, once it has penetrated into plant material, it is metabolised by hydroxylation and conjugation. WATER SOLUBILITY: 146 mg/l at 20℃

Transport Information

Signal Word:CAUTION; Hazard Class:III(Slightly hazardous)