Chemical Identification
Common Name
Ofurace
中文通用名
呋酰胺
IUPAC
(RS)-α-(2-chloro-N-2,6-xylylacetamido)-γ-butyrolactone
CAS
2-chloro-N-(2,6-dimethylphenyl)-N-(tetrahydro-2-oxo-3-furanyl)acetamide
CAS No.
58810-48-3
Molecular Formula
C14H16ClNO3
Molecular Structure
Physical Properties
Molecular weight:281.7; Physical form:Colourless crystals; ( tech. is an off-white to light beige, crystalline powder). Density:1.43 (20℃); Composition:Tech. grade is 97% pure. Melting point:145-146℃; Vapour pressure:2 × 10-2 mPa (20℃); Henry constant:3.9 × 10-5 Pa m3 mol-1 (calc.); Partition coefficient(n-octanol and water):logP = 1.39 (20℃); Solubility:In water 146 mg/l (20 ℃). In acetone 60-75, 1,2-dichloroethane 300-600, ethyl acetate 25-30, methanol 25-30, p-xylene 8.6, heptane 0.0322 (all in g/l).; Stability:Hydrolysis is rapid in alkali, DT50 7 h (pH 9, 35 ℃), but stable in acidic media and at elevated temperatures. Photochemical degradation in water, DT50 7 d.
Toxicology
Oral:Acute oral LD50 for male rats 3500, female rats 2600, mice >5000, rabbits >5000 mg/ kg. Percutaneous:Acute percutaneous LD50 for rabbits >5000 mg/kg. Moderate eye irritant; mild skin irritant (rabbits). Not a skin sensitiser (guinea pigs). Inhalation: LC50 for rats 2060 mg/m3.
Environmental Profile
Ecotoxicology:
Bees:Non-toxic to bees; LD50 (oral) >58 μg/bee.Birds:Acute oral LD50 for red-legged partridge >5000 mg/ kg.Daphnia:EC50 (48 h) 46 mg/l.Fish: LC50 (96 h) for rainbow trout 29, golden orfe 57 mg/l.

Environmental fate:
Animals:Ofurace is rapidly excreted, undergoing extensive phase I and phase II biotransformation.Soil:Degraded in soil, field 50 c. 26 d. Only moderately adsorbed to soil and is considered to be moderately mobile. Undergoes photochemical degradation in water and is degraded in water sediment systems.Plant:Similar metabolic pathways have been detected in vines, tomatoes, and potatoes. Ofurace is relatively stable on the plant surface, but, once it has penetrated into plant material, it is metabolised by hydroxylation and conjugation. WATER SOLUBILITY: 146 mg/l at 20
Transport Information
Signal Word:CAUTION; Hazard Class:III(Slightly hazardous)

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