Brodifacoum

Brodifacoum

溴鼠灵

3-[(1RS,3RS;1RS,3SR)-3-(4′-bromobiphenyl-4-yl)-1,2,3,4-tetrahydro-1-naphthyl]-4-hydroxycoumarin

3-[3-(4′-bromo[1,1′-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl]-4-hydroxy-2H-1-benzopyran-2-one

56073-10-0

C₃₁H₂₃BrO₃

Rodenticides > Coumarin rodenticides

Rodenticide.
Brodifacoum, like other anticoagulant toxicants, works byincreasing (or decreasing) the clotting time of blood, leading to death from haemorrhaging. Brodifacoum isabsorbed through the gastrointestinal tract and can alsobe absorbed through the skin

it is used to control hamsters, mice, rats and other rodents which have proved difficult to control with 
other anticoagulants.

BB = Block bait
RB = Bait
RG =
TKL =
TC = TC

Molecular weight:523.4; Physical form:White powder; (tech., off-white to buff or beige powder). Density:1.42 (25 °C, tech.); Composition:Tech. material is >91% pure. Melting point:228-232 °C ( tech.); Vapour pressure:<<0.001 mPa (20 °C, gas saturation method); Henry constant:<10-1 ( pH 5.2); <10-3 ( pH 7.4); <10-5 ( pH 9.3) (all in Pa m3 mol-1, calc.); Partition coefficient(n-octanol and water):logP = 8.5; pKa:A very weak acid which is too lipophilic to form water-soluble salts.; Solubility:In water 3.8 × 10-3 ( pH 5.2), 0.24 ( pH 7.4), 10 (pH 9.3) (all in mg/l, 20 °C). In acetone 20, chloroform 3, benzene <6 (all in mg/l, 20 °C).; Stability:Thermally (up to 50 °C) and photolytically (30 d in direct sunlight) stable. Degraded by u.v. light when in solution.;

Oral:Acute oral LD₅₀ for male rats 0.4, male rabbits 0.2, male mice 0.4, female guinea pigs 2.8, cats c. 25, dogs 0.25-3.6 mg/kg. Percutaneous:Acute percutaneous LD₅₀ for rabbits 0.25-0.63 mg/kg. Slight to mild skin and eye irritant (rabbits). A moderate skin sensitiser (guinea pigs), but negligible risk of sensitisation from formulated product. Inhalation: LC₅₀ (4 h) 5 mg/l air.

Ecotoxicology: 
Birds:Acute oral LD₅₀ for Japanese quail 11.6, chickens 4.5, mallard ducks 0.31 mg/kg. Dietary LC₅₀ (40 d) for mallard ducks 2.7, bobwhite quail 0.8 ppm.Daphnia: LC₅₀ (48 h) 0.34 mg a.i./l (as formulation).Fish: LC₅₀ (96 h) for bluegill sunfish 0.165, rainbow trout 0.051 mg/l. 

Environmental fate: 
Animals:In mammals, a number of hydroxycoumarins are formed.Soil:Degraded in soils ( pH 5.5 to pH 8) under aerobic and flooded conditions. K_oc (average) 50 000, range 14 000-106 000; K_d 1040 (average), range 625-1320. DT

Signal Word:DANGER; Hazard Class:Ib(Highly hazardous)