Prochloraz

Prochloraz

咪鲜胺

N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide

N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carboxamide

67747-09-5

C₁₅H₁₆Cl₃N₃O₂

Fungicides > Amide fungicides
Fungicides > Imidazole fungicides

Fungicide

Trifloxystrobin+Prochloraz
Tebuconazole+Prochloraz
Pyraclostrobin+Prochloraz
Prochloraz-manganese chloride complex+Pyrimidine nucleoside
Prochloraz-copper+Epoxiconazole
Prochloraz+Thiram
Prochloraz+Sulfur
Prochloraz+Hymexazol
Prochloraz+Fludioxonil
Prochloraz+Ethylicin
Prochloraz+Difenoconazole
Metalaxyl-M+Prochloraz+Clothianidin
Iminoctadine trialbesilate+Prochloraz-manganese
Imidacloprid+prochloraz
Hexaconazole+Prochloraz
Flusilazole+prochloraz
Fenoxanil+Prochloraz
dimethmorph+Prochloraz
Chlorothalonil+prochloraz+triadimefon
Azoxystrobin+Prochloraz+Thiamethoxam
Wettable powder, emulsifiable concentrate, emulsion in water, suspension concentrate. 
Premix Parters: cypermethrin; fenoxycarb lufenuron;

Molecular weight:376.7; Physical form:Odourless, colourless crystals; ( tech. is a mildly aromatic, golden brown liquid, that tends to solidify on cooling). Density:1.42 (20 °C); Composition:Tech. grade is c. 97% pure. Melting point:46.5-49.3 °C (>99% pure); Flash point:160 °C (closed cup); Vapour pressure:1.5 ×10-1 mPa (25 °C); 9.0 ×10-2 mPa (20 °C); Henry constant:1.64 × 10-3 Pa m3 mol-1 ( calc.); Partition coefficient(n-octanol and water):logP = 4.12 (unionised); pKa:3.8, weak base; Solubility:In water 34.4 mg/l (25 °C). Readily soluble in a wide range of organic solvents, e.g. chloroform, diethyl ether, toluene, xylene 2.5, acetone 3.5, hexane c. 7.5 ×10-3 (all in kg/l; Stability:No degradation after 30 d (pH 5-7, 22 °C). Decomposes in concentrated acids and alkalis, in the presence of sunlight, and on prolonged heating at high temperatures (200 °C).

Oral:Acute oral LD₅₀ for rats 1600-2400, mice 2400 mg/ kg. Percutaneous:Acute percutaneous LD₅₀ for rats >2100, rabbits >3000 mg/kg. Not irritating to skin; slight eye irritation (rabbits). Inhalation: LC₅₀ (4 h) for rats >2.16 mg/l air.

Ecotoxicology: 
Algae: E_bC₅₀ (72 h) for Selenastrum capricornutum 0.1 mg/l; E_rC₅₀ 1.54 mg/l.Bees:Low toxicity to bees. LD₅₀ (topical) 50µg/bee; (oral) 60µg/bee.Birds:Acute oral LD₅₀ for bobwhite quail 662, mallard ducks >1954 mg/kg. Dietary LC₅₀ (5 d) for bobwhite quail and mallard ducks >5200 mg/ kg.Daphnia: LC₅₀ (48 h) 4.3 mg/l.Fish: LC₅₀ (96 h) for rainbow trout 1.5, bluegill sunfish 2.2 mg/l.Worms: LC₅₀ for earthworms (Eisenia foetida) 207 mg/ kg soil.Other aquatic spp.: EC₅₀ (96 h) for Eastern oyster (Crassostrea virginica) 0.95, mysid shrimp (Mysidopsis bahia) 0.77 mg/l.Other beneficial spp.:Low toxicity to a range of beneficial arthropods. 

Environmental fate: 
Animals:In all species examined, prochloraz is rapidly metabolised initially by cleavage of the imidazole ring and quantitatively eliminated from the body, following oral administration. Whilst absorption following dermal exposure is low, residues in plasma and tSoil:Degrades in the soil to a range of mainly volatile metabolites (degradation is not pH-dependent). Prochloraz is well adsorbed onto soil particles, and is not readily leached; K_d 152 (sandy loam), 256 (silty claPlant:The primary plant metabolite, N-formyl-N'-1-propyl-N-(2-(2,4,6-trichlorophenoxy)ethyl)urea, is formed from cleavage of the imidazole ring. This is degraded to N-propyl-N-(2-(2,4,6-trichlorophenoxy)ethyl)urea.  WATER SOLUBILITY: Low solubility, 34.4 mg/l at 25°Ced and not readily leached.

Signal Word:CAUTION; Hazard Class:III(Slightly hazardous)