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Physical Properties
Molecular weight:225.3; Physical form:Colourless powder. Density:1.088 (20 °C); Melting point:91-92 °C; Vapour pressure:0.306 mPa (20 °C); Henry constant:9.19 × 10-5 Pa m3 mol-1 ( calc.); pKa:4.3 (21 °C), weak base; Solubility:In water 750 mg/l (20 °C). In benzene >250, methanol, acetone >500, dichloromethane 350, toluene 250 (all in g/l, 20 °C).; Stability:Stable to hydrolysis at 20 °C in neutral, slightly acidic or slightly alkaline media. Hydrolysed by acids or alkalis on warming. Decomposed by u.v. irradiation.
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Toxicology
Tech (Rat): Oral LD50 2980 mg/kg. Inhalation LC50 (4 h) >3.26 mg/l. Pramitol*: Oral LD50 2276 mg/kg (25E), 2745 (5PS). (Rabbit): Dermal LD50 2200 mg/kg.Mild skin irritant; irritating to eyes (rabbits). Phytotoxicity:Not to be used near desired plants.
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Environmental Profile
Ecotoxicology:
Bees:Non-toxic to bees.Birds:Slightly toxic to birds.Fish: LC50 (96 h) for rainbow trout 12, crucian carp 70, bluegill sunfish 40 mg/l.
Environmental fate:
Animals:For metabolism in rats, see J. E. Bakke et al., J. Agric. Food Chem., 1967, 15, 628.Soil:In soil, microbial degradation is the most important route, involving hydrolytic cleavage of the methoxy group to give hydroxy metabolites, and dealkylation of the side-chains. WATER SOLUBILITY: 620 ppm at 20°C HAZARDS: (25E) Fish: LC50 20 mg/l (96 h) (rainbow trout); >32 mg/l (bluegill); 8.6 mg/l (goldfish). Bee: Nontoxic
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Transport Information
Signal Word:WARNING; Hazard Class:II(Moderately hazardous)