Chemical Identification
Common Name
Thiabendazole
中文通用名
噻菌灵
IUPAC
2-(thiazol-4-yl)benzimidazole
or
2-(1,3-thiazol-4-yl)benzimidazole
CAS
2-(4-thiazolyl)-1H-benzimidazole
CAS No.
148-79-8
Molecular Formula
C10H7N3S
Molecular Structure
Category
Activity
Fungicide
Premix
Chlorothalonil+thiabendazole
Azoxystrobin+fludioxonil+metalaxyl-M+thiabendazole
Azoxystrobin+fludioxonil+metalaxyl-M+thiabendazole+thiamethoxam
R-metalaxyl+fludioxonil+azoxystrobin+thiabendazole
Oxine-copper+Thiabendazole
Thiabendazole+Fludioxonil+Metalaxyl-M
Wettable powder, flowable, dust, soluble concentrate, tablet. Premix Parters: diuron;
Physical Properties
Molecular weight:201.3; Physical form:Off-white powder. Density:1.3989; Melting point:297-298 °C; Vapour pressure:4.6 × 10-4 mPa (25 °C); Henry constant:2.7 × 10-8 Pa m3 mol-1; Partition coefficient(n-octanol and water):logP = 2.39 ( pH 7); pKa:pKa1 4.73, pKa2 12.00; Solubility:In water 0.16 ( pH 4), 0.03 ( pH 7), 0.03 ( pH 10) (all in g/l, 20 °C). In n-heptane <0.01, xylene 0.13, methanol 8.28, 1,2-dichloroethane 0.81, acetone 2.43, ethyl acetate 1.49, n-octanol ; Stability:Hydrolytically stable; aqueous photolysis DT50 29 h ( pH 5).;
Toxicology
Oral:Acute oral LD50 for mice 3600, rats 3100, rabbits 3800 mg/kg. Percutaneous:Acute dermal LD50 for rabbits >2000 mg/kg. Non-irritating to eyes and skin (rabbits). Not a skin sensitiser (guinea pigs). Inhalation:LC50 for rats >0.5 mg/kg. (Rat): Oral LD50 3100 mg/kg. Dermal LD50 >2000 mg/kg
Environmental Profile
Ecotoxicology: 
Algae:EC50 (96 h) for Selenastrum 9 mg/l; NOEC for Selenastrum 3.2 mg/l.Bees:Not toxic to bees.Birds:Acute oral LD50 for bobwhite quail >2250 mg/kg. Dietary LC50 (5 d) for bobwhite quail and mallard ducks >5620 mg/kg diet.Daphnia: EC50 (48 h) 0.81 mg/l.Fish: LC50 (96 h) for bluegill sunfish 19, rainbow trout 0.55 mg/l.Worms: LC50 >500 mg/kg soil.Other aquatic spp.: LC50 (96 h) for shrimps 0.34 mg/l, oysters >0.26 mg/l. 

Environmental fate: 
Animals:When administered orally, thiabendazole is rapidly absorbed; up to 90% of the total dose is eliminated (about 65% in urine and 25% in faeces) within 24 h, in both sexes. The compound is rapidly distributed to tissues, with highest levels found in the hearSoil:Soil DT50 33 d (20 °C, 40% MWC, 0.1 mg a.i./kg soil), 120 d (20 °C, 40% MWC, 1 mg a.i./kg soil).Plant:The residue on all crops treated pre- or post-harvest is parent thiabendazole.
Transport Information
Signal Word:CAUTION; Hazard Class:III(Slightly hazardous)

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