Vinclozolin

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Chemical Identification | General Product Information | Physical & Safety Data

Chemical Identification

Common Name

Vinclozolin

中文通用名

乙烯菌核利

IUPAC

(RS)-3-(3,5-dichlorophenyl)-5-methyl-5-vinyl-1,3-oxazolidine-2,4-dione

CAS

3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione

CAS No.

50471-44-8

Molecular Formula

C₁₂H₉Cl₂NO₃

Molecular Structure

General Product Information

Category

Fungicides > Oxazole fungicides
Fungicides > Dicarboximide fungicides

Activity

Fungicide

Premix

Chlorothalonil+vinclozolin

Dry flowable, water dispersible granule, flowable, wettable powder in water soluble bags.
PREMIX PARTNERS:Carbendazim; Chlorothalonil; Thiophanate-methyl; Thiram

Physical & Safety Data

Physical Properties

Molecular weight:286.1g/mol; Physical form:Colourless crystals, with a slight aromatic odour. Density:1.51; Composition:Tech. is 96% m/m pure. Melting point:108℃ (tech.); Vapour pressure:0.13 mPa (20℃); Partition coefficient(n-octanol and water):logP=3 (pH7); Solubility:In water 2.6 mg/l (20℃). In methanol 1.54, acetone 33.4, ethyl acetate 23.3, n-heptane 0.45, toluene 10.9, dichloromethane 47.5 (all in g/100 ml soln., 20℃).Stability:Stable up to 50 ℃. Stable for 24 h in acidic media. In 0.1N sodium hydroxide, 50% hydrolysis occurs in 3.8 h.

Toxicology

Oral Acute oral LD50 for rats and mice >15 000, guinea pigs c. 8000 mg/kg.Skin and eye Acute percutaneous LD50 for rats >5000 mg/kg.Inhalation LC50 (4 h) for rats >29.1 mg/l air.

Environmental Profile

ECOTOXICOLOGY
Birds Acute oral LD50 for quail >2510 mg/kg. LC50 for quail >5620 mg/kg.Fish LC50 (96 h) for trout 22-32, guppies 32.5, bluegill sunfish 50 mg/l.Daphnia LC50 (48 h) 4.0 mg/l.Bees Not toxic to bees. LD50 >200 mg/bee.Worms Not toxic to earthworms.
ENVIRONMENTAL FATE
Animals In the hen, the major metabolic routes are epoxidation of the vinyl group, followed by hydration of the intermediate epoxide, and by hydrolytic cleavage of the heterocyclic ring (G. M. Dean et al., Proc. Br. Crop Prot. Conf. - Pests Dis., 1988, 2, 693-698). In rats, following oral administration, eliminated in approximately equal proportions in the urine and faeces, with the principal metabolite being N-(3,5-dichlorophenyl)-2-methyl-2,3,4-trihydroxybutanamide. Plants In plants, the primary metabolites are (1-carboxy-1-methyl)allyl 3,5-dichlorophenylcarbamate and N-(3,5-dichlorophenyl)-2-hydroxy-2-methyl-3-butenamide. Alkaline hydrolysis leads to loss of 3,5-dichloroaniline from vinclozolin and its metabolites. The metabolites exist as conjugates.Soil/Environment Metabolism occurs by loss of the vinyl group, cleavage of the 5-membered ring and eventual formation of 3,5-dichloroaniline. Koc 100-735. Soil degradation of vinclozolin takes place with half-lives of several weeks, and mainly leads to the formation of bound residues.

Transport Information

Signal Word:CAUTION; Hazard Class:III(Slightly hazardous)