Niclosamide

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Chemical Identification | General Product Information | Physical & Safety Data

Chemical Identification

Common Name

Niclosamide

中文通用名

杀螺胺

IUPAC

2′,5-dichloro-4′-nitrosalicylanilide

CAS

5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

CAS No.

50-65-7

Molecular Formula

C₁₃H₈Cl₂N₂O₄

Molecular Structure

General Product Information

Category

Molluscicides > Molluscicides

Activity

Molluscicide

Premix

Metaldehyde+Niclosamide ethanolamine

Physical & Safety Data

Physical Properties

Molecular weight:327.1g/mol; Physical form:Almost colourless crystals. Melting point:230℃; Vapour pressure:<1 mPa (20℃); Partition coefficient(n-octanol and water):logP = 1 ( pH 9.6); Solubility:In water 1.6 ( pH 6.4), 110 ( pH 9.1) (both in mg/l, 20℃). Soluble in common organic solvents such as ethanol and diethyl ether.; Stability:Hydrolysed in aqueous solution, DT50 (20 ℃) c. 7 d ( pH 6.9), 18.8 d ( pH 13.3). Stable to heat. Decomposes under u.v. irradiation. Hydrolysed by concentrated acid or alkali.

Toxicology

Oral:Acute oral LD₅₀ for rats >5000 mg/ kg. Percutaneous:Acute percutaneous LD₅₀ for rats >1000 mg/ kg (EC250). Strong eye irritant; skin reacts after repeated and long-lasting exposure (rabbits). Inhalation: LC₅₀ for rats (1 h) 20 mg/l air.

Environmental Profile

Ecotoxicology:
Bees:No significant mortality effects.Birds: LD₅₀ for mallard ducks >500 mg/ kg.Daphnia: LC₅₀ (48 h) 0.2 mg/l.Fish: LC₅₀ (96 h) for golden orfe 0.1 mg/l.

Environmental fate:
Animals:Following oral administration, ¹⁴C-niclosamide was absorbed and metabolised in the rat. The major metabolite in the urine was the reduced compound 2',5-dichloro-4'-aminosalicylanilide ([10558-45-9]); several labile conjugates Soil:There was a rapid decline in niclosamide residues in paddy water; degradation followed pseudo-first order kinetics, DT₅₀ 0.3 d.

Transport Information

Signal Word:CAUTION; Hazard Class:III(Slightly hazardous)