Coumatetralyl

Coumatetralyl

杀鼠醚

4-hydroxy-3-[(1RS)-1,2,3,4-tetrahydro-1-naphthyl]coumarin

4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-2H-1-benzopyran-2-one

5836-29-3

C₁₉H₁₆O₃

Rodenticides > Coumarin rodenticides

Rodenticide

Molecular weight:292.3; Physical form:Colourless crystals; (tech., yellowish crystals). Melting point:172-176 °C; (tech., 166-172 °C); Vapour pressure:8.5×10-6 mPa (20 °C); Henry constant:1×10-7 Pa m3 mol-1 (pH 5, 20 °C); Partition coefficient(n-octanol and water):logP = 3.46; pKa:4.5-5.0; Solubility:In water 4 (pH 4.2), 20 (pH 5), 425 (pH 7) (all in mg/l, 20 °C), 100-200 g/l (pH 9, 20 °C). Readily soluble in dimethylformamide. Soluble in alcohols and acetone. Slightl; Stability:Thermally stable up to at least 150 °C. Not hydrolysed by water over 5 d (25 °C); DT50 >1 y (pH 4-9). Rapidly decomposed in aqueous solutions exposed to sunlight or u.v. light. Soluble in dichloromethane, 2-propanol; hardly soluble in toluene; nearly insoluble in n-hexane.

Oral:Acute oral LD₅₀ for rats 16.5, mice >1000, rabbits >500 mg/kg. Sub-chronic oral LD₅₀ (5 d) for rats 0.3 mg/kg/day. Percutaneous:Acute percutaneous LD₅₀ for rats 100-500 mg/kg. Inhalation:LC₅₀ (4 h) for rats 39, mice 54 mg/m³. ADI:(JMPR) No ADI [1990]; for 'Perizin' 0.035 mg/kg.

Ecotoxicology: 
Algae:E_rC₅₀ >18 mg/l, E_bC₅₀ (72 h) 15.2 mg/l.Birds:Acute oral LD₅₀ for Japanese quail >2000 mg/kg b.w. Dietary LC₅₀ (8 d) for hens >50 mg/kg daily.Daphnia:LC₅₀ (48 h) >14 mg/l.Fish:LC₅₀ (96 h) for guppies c. 1000, rainbow trout 48, golden orfe 67 mg/l. Environmental fate: 
Soil:BBA-standard soil 2.2 (aerobic conditions); 51% mineralisation in 90 days. 
WATER SOLUBILITY: 20 mg/l at 20° C (pH 5)

Signal Word:DANGER; Hazard Class:Ib (Highly hazardous)