Cymoxanil

Cymoxanil

霜脲氰

1-[(EZ)-2-cyano-2-methoxyiminoacetyl]-3-ethylurea

2-cyano-N-[(ethylamino)carbonyl]-2-(methoxyimino)acetamide

57966-95-7

C₇H₁₀N₄O₃

Fungicides > Aliphatic nitrogen fungicides

Fungicide

Trifloxystrobin+Cymoxanil
Pyraclostrobin+Cymoxanil
Propineb+Cymoxanil
Oxine-copper+Cymoxanil
Mancozeb+cymoxanil
Cymoxanil+Metiram
Cymoxanil+metalaxyl
Cymoxanil+famoxadone
Cymoxanil+enestroburin
Cymoxanil+cyazofamid
Cymoxanil+Cuprous oxide
Chlorothalonil+cymoxanil
Azoxystrobin+cymoxanil
Premix Parters: chlorpyrifos; chlorpyrifos ethofumesate metamitron.

Molecular weight:198.2; Physical form:Colourless, odourless crystals; ( tech. is a peach colour). Density:1.31 (25 °C); Composition:Tech. is >95%. Melting point:160-161 °C; ( tech., 159-160 °C). Specific gravity 1.31 at 25°C. Vapour pressure:0.15 mPa (20 °C); Henry constant:3.8×10-5 ( pH 7), 3.3×10-5 ( pH 5) (both Pa m3 mol-1, calc.); Partition coefficient(n-octanol and water):logP = 0.59 ( pH 5), 0.67 ( pH 7); pKa:9.7 ( decomp.); Solubility:In water 890 mg/kg( pH 5, 20 °C). In hexane 1.85, toluene 5.29, acetonitrile 57, ethyl acetate 28, n-octanol 1.43, methanol 22.9, acetone 62.4, methylene chloride 133.0 (all in g/l, 20 °C).; Stability:Hydrolysis DT50 148 d ( pH 5), 34 h ( pH 7), 31 min ( pH 9). Aqueous photolysis DT50 1.8 d ( pH 5). Solubility: dimethylformamide 18.5g/100g solvent; acetone 10.5; chloroform 10.3; methanol 4.1; benzene 0.2; hexane < 0.1.

Oral:Acute oral LD₅₀ for male and female rats 960 mg/kg. Percutaneous:Acute percutaneous LD₅₀ for rabbits >2000 mg/kg. Not an eye irritant; slight skin irritant (rabbits). Not a skin sensitiser (guinea pigs). Inhalation: LC₅₀ (4 h) for male and female rats >5.06 mg/l. ADI:( JMPR) 0.007 mg/kg b.w. [1994] (with azocyclotin).

Ecotoxicology: Algae:23% Inhibition of Selenastrum capricornutum at 1.05 mg/l after 5 d; EC₅₀ for Anabaena flos-aquae 231 ppb.Bees:Not toxic to bees; LD₅₀ (48 h, contact) >25 μg/bee; LC₅₀ (48 h, oral) >1000 ppm.Birds:Acute oral LD₅₀ for bobwhite quail and mallard ducks >2250 mg/kg.(a.i.) LC₅₀ 2847 ppm (8 day) (quail); >10,000 ppm (mallard). Dietary LC₅₀ (8 d) for bobwhite quail and mallard ducks >5620 mg/kg diet.Daphnia: LC₅₀ (48 h) 27 mg/l.Fish: LC₅₀ (96 h) for rainbow trout 61, bluegill sunfish 29, common carp 91, sheepshead minnow >47.5 mg/l. Worms: LC₅₀ (14 d) >2208 mg/kg soil.Other aquatic spp.: LC₅₀ (96 h) for Eastern oyster >46.9, mysid shrimp >44.4 ppm. Environmental fate: Animals:In rats, cymoxanil was readily absorbed through the intestines; the majority of the dose was excreted in the urine. The proposed metabolic pathway involves hydrolysis of cymoxanil and then degradation to glycine.Soil:In lab. soils, DT₅₀ 0.75-1.5 d (5 soils, pH range 5.7-7.8, o.m. 0.8-3.5%). In the field, DT₅₀ (bare soil) 0.9-9 d. In aquatic studies, DT₅₀ Plant:Degraded to glycine with subsequent incorporation into natural products (proteins and starch). SOIL PARTICLE ADSORPTION: Normal conditions, half-life in soil <2 weeks WATER SOLUBILITY: 1000 ppm

Signal Word:WARNING; Hazard Class:II (Moderately hazardous)