Chemical Identification
Common Name
4-hydroxy-3-[(1RS,3RS;1RS,3SR)-1,2,3,4-tetrahydro-3-[4-(4-trifluoromethylbenzyloxy)phenyl]-1-naphthyl]coumarin (mixture of cis- to trans- isomers in the ratio range 60:40 to 40:60 respectively)
Molecular Formula
Molecular Structure
Physical Properties
Molecular weight:542.6; Physical form:Off-white solid. Melting point:cis- isomer 181-191 °C; trans- isomer 163-166 °C; Vapour pressure:1.33 × 10-7 mPa (25 °C); Partition coefficient(n-octanol and water):logP = 4.7; Solubility:In water 1.1 mg/l. In acetone >600, ethanol 34, xylene 33, octanol 44 (all in g/l).; Stability:Stable to hydrolysis; at 50 °C and pH 7-9, no detectable degradation occurred in 4 weeks. Thermally stable up to 250 °C.;
Oral:Acute oral LD50 for rats 0.25, mice 0.8, dogs 0.075-0.25, rabbits 0.2, hamsters >50, gerbils 0.18, cats >10, goats >10, sheep >5, pigs c. 60 mg/ kg. Percutaneous:Acute percutaneous LD50 for rats <3 mg tech./ kg. Inhalation: LC50 (4 h) for rats 0.16-1.4 mg/l (using 0.5% manufacturing master mix, as dust).
Environmental Profile
Birds:Acute oral LD50 for chickens >100, Japanese quail >300, mallard ducks c. 24 mg/kg. Dietary LC50 (5 d) for Japanese quail 37, mallard ducks 1.7 mg/ Daphnia: LC50 (48 h) immobilisation 0.66 mg/l nominal.Fish:Baits (50 mg a.i./ kg) are non-toxic to aquatic species. LC50 (96 h) for carp 0.15 mg/l. 

Environmental fate: 
Animals:In rats ( i.v.) (Xenobiotica, 1989, 19, 51) and Japanese quail (oral, i.p.) (Xenobiotica, 1989, 19, 63), flocoumafen is metabolised to a number of hydroxycoumarins.
Transport Information
Signal Word:CAUTION; Hazard Class:Ia(Extremely hazardous)

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