Chemical Identification
Common Name
Mefluidide
中文通用名
氟磺酰草胺
IUPAC
5′-(1,1,1-trifluoromethanesulfonamido)acet-2′,4′-xylidide
CAS
N-[2,4-dimethyl-5-[[(trifluoromethyl)sulfonyl]amino]phenyl]acetamide
CAS No.
53780-34-0
Molecular Formula
C11H13F3N2O3S
Molecular Structure
Physical Properties
Molecular weight:310.3; Physical form:Colourless, odourless crystals. Melting point:183-185 °C; Vapour pressure:<10 mPa (25 °C); Henry constant:<1.72 × 10-2 Pa m3 mol-1 ( calc.); Partition coefficient(n-octanol and water):logP = 2.02 (25 °C, unionised, K. Chamberlain et al., Pestic. Sci., 47, 265 (1996)); pKa:4.6; Solubility:In water 180 mg/l (23 °C). In acetone 350, methanol 310, acetonitrile 64, ethyl acetate 50, n-octanol 17, diethyl ether 3.9, dichloromethane 2.1, benzene 0.31, xylene 0.12 (all in g/l, 23 °C).; Stability:Stable at elevated temperatures, but the acetamido moiety is hydrolysed on refluxing mefluidide in acidic or alkaline solutions; degraded in aqueous solutions exposed to u.v. radiation.;
Toxicology
Oral:Acute oral LD50 for rats >4000, mice 1920 mg/ kg. Percutaneous:Acute percutaneous LD50 for rabbits >4000 mg/kg. Mild eye irritant; non-irritating to skin (rabbits).
Environmental Profile
Ecotoxicology: 
Bees:Not toxic to bees.Birds:Acute oral LD50 for mallard ducks and bobwhite quail >4620 mg/kg. Dietary LC50 (5 d) for mallard ducks and bobwhite quail >10 000 mg/ kg diet (observFish:LC50 (96 h) for rainbow trout and bluegill sunfish >100 mg/l. 

Environmental fate: 
Animals:In mammals, following oral administration, mefluidide residues are excreted intact.Soil:Rapidly degraded in soil, DT50 <1 w. 5-Amino-2,4-dimethyltrifluoromethanesulfonanilide is found as a metabolite.
Transport Information
Signal Word:CAUTION; Hazard Class:III(Slightly hazardous)

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