Flurochloridone

Flurochloridone

氟咯草酮

a mixture of the enantiomeric pairs (3RS,4RS;3RS,4SR)-3-chloro-4-chloromethyl-1-(α,α,α-trifluoro-m-tolyl)-2-pyrrolidone (isomers in the ratio 3:1)

3-chloro-4-(chloromethyl)-1-[3-(trifluoromethyl)phenyl]-2-pyrrolidinone

61213-25-0

C₁₂H₁₀Cl₂F₃NO

Flurochloridone is a selective pre-emergence residual herbicide of the pyrrolidone group for control of many broadleaf and some grass weeds in sunflowers, potatoes, carrots, parsley, dill, coriander, chickpeas, winter wheat, winter rye, maize and sugar cane.

Flurochloridone is taken up by the roots of the plants and is quickly translocated to the foliar tissues in susceptible plants. Germinating weeds are killed before emergence or emerge bleached and quickly die.

Capsule suspension, emulsifiable concentrate. 
Premix Parters: aclonifen; diflufenican; diflufenican isoproturon;

Molecular weight:312.1; Physical form:Brown-beige, waxy solid. Density:1.19 (20 °C); Composition:A mixture of cis- and trans- isomers in the ratio 1:3. Melting point:40.9 °C (eutectic); 69.5 °C (trans- isomer); Vapour pressure:0.44 mPa (25 °C); Henry constant:3.9 × 10-3 Pa m3 mol-1 ( calc.); Partition coefficient(n-octanol and water):logP = 3.36; Solubility:In water 35.1 (distilled), 20.4 ( pH 9) (both in mg/l, 25 °C). In ethanol 100, kerosene <5 (both in g/l, 20 °C). Readily soluble in acetone, chlorobenzene, and xylene.; Stability:Stable to hydrolysis at pH 5, 7 and 9 (25 °C); in acidic media and at elevated temperatures, decomposition occurs; DT50 138 d (100 °C), 15 d (120 °C). DT50 (60 °C) 7 d PH

Oral:Acute oral LD₅₀ for male rats 4000, female rats 3650 mg/ kg. Percutaneous:Acute percutaneous LD₅₀ for rabbits >5000 mg/ kg; practically non-irritating to skin, not irritant to eyes (rabbits). Not a skin sensitiser (guinea pigs). Inhalation: LC₅₀ (4 h) for rats >0.121 mg/l air.

Ecotoxicology: 
Algae: E_bC₅₀ (96 h) for Chlorella vulgaris 0.0064 mg/l.Bees:Not hazardous to bees. LD₅₀ (contact and oral) >100 μg/bee.Birds:Acute oral LD₅₀ for bobwhite quail >2000 mg/kg. Dietary LC₅₀ (5 d) for mallard ducks and bobwhite quail >5000 mg/ kg diet.Daphnia: LC₅₀ (48 h) 5.1 mg/l.Fish: LC₅₀ (96 h) for rainbow trout 3.0, bluegill sunfish 6.7 mg/l.Worms: LC₅₀ 691 mg/ kg.Other beneficial spp.:Harmless to carabid beetles, Lycosid spider, Aphidius and Typhlodromus. 

Environmental fate: 
Animals:Flurochloridone is extensively metabolised and rapidly excreted in rats; >95% of orally applied dose was excreted in 90 h. Metabolism by oxidation, hydrolysis and glutathione conjugation yielded numerous metabolites in urine and faeces.Soil:In the lab., flurochloridone is readily degraded in soil, mostly forming CO₂ and a bound residue; DT₅₀ (3 soil types, aerobic, 28 °C) 4, 5 and 27 d; two metabolites were formed, which were readily degraded further. InPlant:Flurochloridone is rapidly metabolised in plants. Numerous minor metabolites are formed through oxidation and conjugation. Residue levels of flurochloridone in crops are generally <0.05 mg/ kg.

Signal Word:CAUTION; Hazard Class:III(Slightly hazardous)