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Common Name
Carbofuran
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中文通用名
克百威
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IUPAC
2,3-dihydro-2,2-dimethylbenzofuran-7-yl methylcarbamate
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CAS
2,3-dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate
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CAS No.
1563-66-2
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Molecular Formula
C12H15NO3
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Molecular Structure
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Category
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Activity
Insecticide
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Premix
Granule, flowable, wettable powder, flowable concentrate for seed treatments. Premix Parters: zeta-cypermethrin; zeta-cypermethrin imidacloprid; pyridaben;
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Physical Properties
Molecular weight:221.3; Physical form:Colourless crystals. Density:1.18 (20 °C); Melting point:153-154 °C; (tech. 150-152 °C); Vapour pressure:0.031 mPa (20 °C); 0.072 mPa (25 °C); Partition coefficient(n-octanol and water):logP = 1.52 (20 °C); Solubility:In water 320 (20 °C), 351 (25 °C) (both in mg/l). In dichloromethane >200, isopropanol 20-50, toluene 10-20 (all in g/l, 20 °C).; Stability:Unstable in alkaline media. Stable in acidic and neutral media. Decomposes >150 °C. DT50 (22 °C) >>1 y (pH 4), 121 d (pH 7), 31 h (pH 9). Readily soluble in dichloromethane; soluble in 2-propanol; barely soluble in toluene.
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Toxicology
Oral:Acute oral LD50 for male and female rats c. 8 mg/kg, dogs 15 mg/kg, mice 14.4 mg/kg. Percutaneous:Acute percutaneous LD50 (24 h) for male and female rats >2000 mg/kg; mildly irritating to skin and eyes (rabbits).Dermal LD50 >3000 mg/kg. Inhalation:LC50 (4 h) for male and female rats c. 0.075 mg/l air (aerosol).
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Environmental Profile
Ecotoxicology: Bees:Toxic to bees (except for granular formulation).Birds:Acute oral LD50 for Japanese quail 2.5-5 mg/kg. LC50 for Japanese quail 60-240 mg (as GR5)/kg. Daphnia:LC50 (48 h) 38.6 mg/l.Fish:LC50 (96 h) for rainbow trout 22-29 mg (as GR5)/l, bluegill sunfish 1.75 mg(as GR3)/l, golden orfe 107-245 mg (as GR5)/l. Tech.: 7.3-362.5 mg/l, depending on species. Environmental fate: Animals:Carbofuran is metabolised by hydrolytic and oxidative mechanisms in the rat. At 24 hours after treatment, 72% of the dose was eliminated in the urine, 2% in the faeces, and about 43% of the administered dose was hydrolysed. Over 95% of the material excretSoil:DT50 in soil c. 30-60 d. Most important metabolite is CO2 formed by microbiological degradation of the phenol compounds. Koc 22.Plant:Carbofuran is quickly metabolised into 3-hydroxycarbofuran and ketocarbofuran. WATER SOLUBILITY: 351 ppm.
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Transport Information
Signal Word:WARNING; Hazard Class:Ib (Highly hazardous)