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Common Name
Fluxofenim
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中文通用名
氟草肟
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IUPAC
4′-chloro-2,2,2-trifluoroacetophenone (EZ)-O-1,3-dioxolan-2-ylmethyloxime
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CAS
1-(4-chlorophenyl)-2,2,2-trifluoroethanone O-(1,3-dioxolan-2-ylmethyl)oxime
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CAS No.
88485-37-4
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Molecular Formula
C12H11ClF3NO3
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Molecular Structure
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Category
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Activity
Herbicide Safener
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Physical Properties
Molecular weight:309.7; Physical form:Colourless, oily liquid. Density:1.36 (20 °C); Composition:Material comprises both (Z)- and (E)- isomers. Flash point:>93 °C; Vapour pressure:38 mPa (20 °C); Henry constant:3.92 × 10-1 Pa m3 mol-1 ( calc.); Partition coefficient(n-octanol and water):logP = 2.9 ( rp-tlc method); Solubility:In water 30 mg/l (20 °C). Miscible with common organic solvents (acetone, methanol, toluene, hexane, octanol).; Stability:Stable 200 °C. Hydrolytically stable (>300 d, 50 °C, pH 5-9).;
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Toxicology
Oral:Acute oral LD50 for rats 670 mg/ kg. Percutaneous:Acute percutaneous LD50 for rats 1540 mg/kg. Not a skin or eye irritant. Not a skin sensitiser. Inhalation: LC50 (4 h) for rats >1.2 mg/l. ADI:0.01 mg/ kg b.w.
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Environmental Profile
Ecotoxicology:
Birds:Acute oral LD50 for bobwhite quail >2000 mg/kg. Oral LC50 (8 d) for bobwhite quail >5000 ppm.Daphnia: LC50 (48 h) 0.22 mg/l.Fish: LC50 for trout 0.86, bluegill sunfish 2.5 mg/l.
Environmental fate:
Animals:In the rat, fluxofenim is rapidly absorbed and rapidly excreted via urine and faeces, with low tissue residues. Metabolism proceeds via hydrolysis of the dioxolane ring and subsequent oxidation steps, followed by cleavage of the oxime ether.
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Transport Information
Signal Word:CAUTION; Hazard Class:II(Moderately hazardous)