Metalaxyl-M

Metalaxyl-M

精甲霜灵

methyl N-(methoxyacetyl)-N-(2,6-xylyl)-D-alaninate

methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)-D-alaninate

70630-17-0

C₁₅H₂₁NO₄

Fungicides > Anilide fungicides

Fungicide.Metalaxyl-M is a systemic apoplastically transported fungicide, which is highly active against fungi of the order Peronosporales. Issues of developing resistance of Phytophthora erythrosceptica in potatoes in the US have been reported (BCPC, 2000). Areas include the NE and Idaho. The frequency of resistance in populations sampled increased from 79% in 1998 to 100% in 1999. Ridomil Gold performed well as an in-furrow treatment to control seedling diseases in cotton in the US.

CropUses:
alfalfa, beans, beets, carrots, citrus, cotton, grapes, grass, lucerne, maize, ornamentals, peas, peppers, potatoes, sorghum, soybeans, strawberries, sunflower, sweetcorn, tobacco, tomatoes, turf, vegetables

Grapes: 10 g ai/hl	foliar use
Potatoes: 100 g ai/ha	foliar use
Tobacco: 12 g ai/hl	foliar use
Citrus: 1 g ai/m2 around the tree	soil use
Peppers: 1 kg ai/treated ha	soil use
Cotton: 15 g ai/100 kg seed	seed treatment
Maize: 70 g ai/100 kg seed	seed treatment
Sunflower: 105 g/ 100 kg seed	seed treatment

Thiamethoxam+metalaxyl-M
Thiamethoxam+fludioxonil+metalaxyl-M
Thiamethoxam+fludioxonil+metalaxyl-M
thiamethoxam+difenoconazole+metalaxyl-M+sedaxane+fludioxonil
Thiamethoxam+difenoconazole+metalaxyl-M
Thiamethoxam+difenoconazole+fludioxonil+metalaxyl-M
Thiamethoxam+azoxystrobin+fludioxonil+metalaxyl-M
Thiamethoxam+abamectin+azoxystrobin+fludioxonil+metalaxyl-M
Thiabendazole+Fludioxonil+Metalaxyl-M
sedaxane+fludioxonil+metalaxyl-M
Pyraclostrobin+Metalaxyl-M
Propamocarb hydrochloride+Metalaxyl-M
Metalaxyl-M+Tebuconazole+Azoxystrobin
Metalaxyl-M+Propineb
Metalaxyl-M+Prochloraz+Clothianidin
Metalaxyl-M+mancozeb
Metalaxyl-M+Fludioxonil+Triticonazole
Metalaxyl-M+Fludioxonil
Metalaxyl-M+Fludioxonil
Metalaxyl-M+Cuprous oxide
Metalaxyl-M+azoxystrobin
Flumorph+Metalaxyl-M
difenoconazole+metalaxyl-M+sedaxane+fludioxonil
Chlorothalonil+metalaxyl-M
Azoxystrobin+metalaxyl-M
Azoxystrobin+fludioxonil+metalaxyl-M+thiabendazole+thiamethoxam
Azoxystrobin+fludioxonil+metalaxyl-M+thiabendazole
Azoxystrobin+fludioxonil+metalaxyl-M
Emulsifiable concentrate, granule, liquid solution, wettable powder. Premix Parters: clomazone; quinmerac;

Type	AI concn
GR	1-2.5 % for soil use
EC	48 % w/v for soil use
ES, LS (straight & mixture products)	1-35% w/v for seed treatments
WP, WG, SC (mixture products)	3-4 % ai for foliar use

Molecular weight:279.3; Physical form:Pale yellow to light brown, viscous liquid. Density:1.125 (20 °C); Composition:(R)- enantiomer of metalaxyl. Melting point:-38.7 °C (glass transition temperature); Flash point:179 °C (EEC A10); Vapour pressure:3.3 mPa (25 °C); Henry constant:3.5×10-5 Pa m3 mol-1 ( calc.); Partition coefficient(n-octanol and water):logP = 1.71 (25 °C); Solubility:In water 26 g/l (25 °C). In n-hexane 59 g/l; miscible with acetone, ethyl acetate, methanol, dichloromethane, toluene, n-octanol.; Stability:Hydrolytically stable under acidic and neutral conditions ( DT50 >200 d). Under alkaline conditions, DT50 116 d ( pH 9, 25 °C).;

Oral:Acute oral LD₅₀ for rats 667 mg/ kg. Percutaneous:Acute percutaneous LD₅₀ for rats >2000 mg/kg. Not a skin irritant (rabbits); risk of serious damage to eyes (rabbits). Not a skin sensitiser (guinea pigs). Inhalation: LC₅₀ (4 h) for rats >2290 mg/m³. ADI:( JMPR) 0.03 mg/ kg b.w. [1982]; (Novartis) 0.025 mg/ kg b.w.

Ecotoxicology:?
Algae: E_rC₅₀ (72 h) for Scenedesmus subspicatus 103 mg/l.Bees: LD₅₀ (48 h, contact) 25 mg/bee.Birds: LD₅₀ (14 d) for bobwhite quail 981-1419 mg/kg. LC₅₀ (8 d) for bobwhite quail >5620 mg/ kg.Daphnia: LC₅₀ (48 h) >100 mg/l.Fish: LC₅₀ (96 h) for rainbow trout >100 mg/l.Worms: LC₅₀ (14 d) for Eisenia foetida 830 mg/ kg soil.Other aquatic spp.: EC₅₀ (96 h) for Eastern oyster (Crassostrea virginica) 9.7 mg/l.Other beneficial spp.:EC formulation (480 g/l ) harmless to Poecilus cupreus and Orius insidiosus ( IOBC).?

Environmental fate:?
Animals:In mammals, following oral administration, rapidly absorbed and also rapidly and almost completely eliminated in urine and faeces. Metabolism proceeds via hydrolysis of the ester bond, oxidation of the 2-(6)-methyl group and of the phenyl ring and N-dealkSoil: DT₅₀ in soil 21 d (realistic range 5-30 d). K_oc 70 ml/g (realistic range 30-300 ml/g). Stable to photolysis.Plant:Metabolised by more than 4 types of phase I reaction (oxidation of the phenyl ring, oxidation of the methyl group, cleavage of the methyl ester and N-dealkylation) to form eight metabolites; at phase II, most of the metabolites are sugar conjugated.

Hazard Class:II(Moderately hazardous)