Triazole fungicide are used on many different types of plants including field crops, fruit trees, small fruit, vegetables and turf. These fungicides are highly effective against many different fungal diseases, especially powdery mildews, rusts, and many leaf-spotting fungi.

The triazole fungicides inhibit one specific enzyme, C14-demethylase, which plays a role in sterol production. Sterols, such as ergosterol, are needed for membrane structure and function, making them essential for the development of functional cell walls. Therefore, these fungicides result in abnormal fungal growth and eventually death.

Each triazole compound may act in a slightly different part of the biochemical sterol-producing pathway. While the results are similar in various fungi--abnormal fungal growth and death--there are great differences in the activity spectra of these fungicides.

Triazoles have no effect against spore germination because spores contain enough sterol for the formation of germ tubes. Some spores even have enough sterol to produce infection structures so, in some cases, triazoles may not be effective against infection of the host tissue.

Triazoles may be applied preventively or as early-infection treatments. When applied as an early-infection treatment, applications must be made early in the fungal infection process. Some triazole fungicides have anti-sporulant properties, which means they inhibit spore production and therefore help to slow disease development. However, if a fungus begins to produce spores on an infected plant, triazole fungicides are then not effective.

Although the triazoles don't have the degree of systemic movement of many herbicides, they are locally systemic and more mobile in plant tissues than QoI fungicides. Following application, the active ingredient is readily taken up by leaves and moves within the leaf. Studies have shown that three droplets of a labeled rate of triazole fungicide applied to a soybean trifoliate leaf covered the entire leaf within one day.

Note, however, that triazole fungicides are not necessarily transported from one leaf to another leaf or from one part of the plant to another part. They also do not move down plants through the phloem. Most triazoles have a residual period of approximately 14 days.

There have been scattered reports of injury on soybean associated with triazole applications, especially tebuconazole. Of the reports of tebuconazole injury, applications were made during hot and dry conditions and with a surfactant.

Since their site of action is very specific, there are some resistance concerns. Resistance has occurred on other plant pathogens, even some rusts. Some of the triazoles have disappeared from the marketplace as resistance to them developed and they no longer provided any benefit or advantage in a disease control program.

Recommendations for avoiding fungicide resistance:

* Repeated use of triazoles alone should be avoided, especially under high disease pressure or against rapid cycling diseases such as rust.

* When multiple applications are required, alternate or tank mix triazole fungicides with fungicides with a different mode of action (not just different triazoles). The other fungicide has to provide effective disease control. Refer to label recommendations for rates.

* Apply triazole fungicides according to manufacturers' recommendations for the target disease at the specific crop growth stage indicated. Use during the critical parts of the growing season or crop growth, especially when alternative fungicides are not available or effective.

* If possible, apply triazole fungicides preventively or as early as possible in the disease cycle. While some triazole fungicides have early-infection activity, do not rely on management of diseases when fungicides are applied well after disease has progressed.

* Reduced rate programs accelerate the development of resistant populations and therefore must not be used.